Notes
Slide Show
Outline
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Testosterone Therapy for The Mature Man-Who and How
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Male Sexual Chemistry
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Hypothalamic-Pituitary-Gonadal Axis
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Pulsatile GnRH Secretion
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Causes of Hypogonadism
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Healthy Men with Testosterone Deficiency
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Age -Total T- freeT index
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Measuring Testosterone
  • Assay
  • Total Testosterone
  • Free T analogue
  • Bioavailable T
  • Free T by dialysis
  • Measures What?
  • T+SHBG+AlbT
  • ? Probably free T
  • T  after NH2SO4 ppt
  • Free T
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When is a Man Testosterone Deficient?
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Testosterone Deficiency
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Low T and ED-2 Views
  • Endocrinology –Low T
  • Common in ED-35%
  • Related to ED
  • T Rx.
  •     a. Normal NPT/VSS
  •     b. CC NOS
  •     c. Effective


  • Urology-Low T
  • Rare in ED -1%
  • NPT Castrati
  • Unrelated to ED
  • T Rx.
  •     a. Libido only
  •     b. Unproven
  •     c. Effective*


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Effect of Age on Nocturnal Penile Tumescence
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Androgen Rx.-Expectations
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NPT Episodes and Serum Testosterone
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The Nitric Oxide Cascade
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Androgen Rx.-Expectations
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Effect of T 100 mg/wk on Grip Strength
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Weight and Strength after 10 wks of T 600 mg/wk
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Effect of T 100 mg/wk on weight, muscle and fat
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Androgen Rx.-Expectations
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Perception of Physical Function
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 Androgen Delivery Systems
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Testosterone after Patch, Gel or Injection
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Serum Testosterone with Androgel
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Contraindications to Androgen Therapy
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Sudden Testosterone Deficiency
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Treating Hot Flashes in Men
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Will Testosterone Rx. Adversely Affect ?
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Conclusions- Testosterone for the T deficient Mature Man
  • Benefits
  • Anabolic
  • Lipolytic
  • Libido
  • Erectile Function
  • Well-being
  • Risks
  • Hct. With IM T
  • PSA
  • ?Acne
  • Male pattern baldness
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